Here's a blast from the past: Moleculous

Continuing our 'Road To The IGF' feature, profiling and interviewing each of the
finalists in the 2006 Independent Games
Festival main competition, today's profile takes a look at SMERC, the
developers for the scientific puzzle game Moleculous, which is a finalist
for the Best Web Browser Game award at the 2006 IGF. The developers' description
of this educational puzzle quest to discover cold fusion explains:
"Strap on
your lab goggles and get your daily dose of science with Moleculous. Those messy
fossil fuels that everyone depends on are running out, and now it's up to you to
discover Cold Fusion before the world's energy supply disappears!"

The Gamasutra Article